Registration Number
2122U008349, Article
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Стаття
Title
Ovarian toxicity of fac chemotherapy in rats and possibility of its correction with platelet-rich plasma
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Shamrai V. A.
Misiurko O. I.
Grebeniuk D.I.
Taran I.V.
Shamrai V. A.
Misiurko O. I.
Grebeniuk D.I.
Taran I.V.
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01-01-2022
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Вінницький національний медичний університет ім. М. І. Пирогова
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https://dspace.vnmu.edu.ua/123456789/8388
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Experimental Oncology
Description
To compare the dynamics of changes in the hormonal status of female rats in the setting of the FAC (5-fluorouracil, doxoru-bicin and cyclophosphamide) chemotherapy and after local administration of platelet-rich plasma (PRP). Materials and Methods: The study was carried out on female Wistar rats treated according to the FAC chemotherapy scheme (4 courses with a 3-week interval). The ovariotoxic effect of the FAC chemotherapy was assessed by the levels of anti-Mullerian hormone, estradiol (E2) and follicle-stimulating hormone in the proestrus phase. Three weeks after the last course of chemotherapy, 5 rats were administered with local intra- and periovarian injection of PRP (triply with a 1-week interval). Results: The dynamics of all investigated hormonal markers of the ovarian reserve in experimental animals was characterized by a progressive decrease in anti-Mullerian hormone and E2 levels and an increase in follicle-stimulating hormone level. The dynamics of the studied parameters after the serial administration of PRP demonstrated an improvement in the hormonal status. Conclusion: FAC chemotherapy in the experiment causes premature ovarian failure, and local administration of PRP improves the hormonal parameters of the ovarian reserve.
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2026-09-16
