Registration Number
0120U104977,
(
0225U004568
)
R & D request
Title
Functional design, synthesis and directed modification of bioattractive condensed azole, azine and azepine compounds
Head
Vovk Mykhailo V., Доктор хімічних наук
Registration Date
19-11-2020
Organization
Institute of Organic Chemistry NAS of Ukraine
popup.description1
The purpose of the work is to create methodological bases for designing new promising for organic synthesis and biomedical research types of azole-azole (pyrrolothiazoles, imidazothiazoles), azole-azine (pyrazolopyridines, pyrazolopyrimidines, pyrazolopyrazines, 1,2,3-triazolopyridines, 1,2,3-triazolopyrimidines, pyrroloquinazolines) and azolo-azepine (pyrazoloazepines, 1,2,3-triazoloazepines) compounds, structurally modified by linear-functional and heteroanelated fragments. In this case, considerable attention will be focused on the design of those condensed derivatives that contain key for further synthetic transformations haloalkyl, formyl, carboxyl, alkenyl, alkynyl, amino and hydrazino groups. To achieve this goal, the known and new, especially catalytic, methods of functionalization and annelation of small and medium heterocyclic nuclei to basic azole and azine templates will be significantly improved and developed. An important role in the research process will be assigned to the establishment of patterns of regio- and stereocontrol in the implementation of highly selective cyclization methods for the directed synthesis of condensed heterocyclic compounds as molecular platforms for the design of bioactive substances. The pronounced pharmacological properties of functional derivatives of heteroanylelated azoles, azines and azepines seem to be an important basis both for the development of effective synthetic approaches to their new representatives and for selective modification to obtain compounds with a wide segment of biological action.
popup.nrat_date
2024-12-10
