Registration Number
0211U005892,
0111U002043
, R & D reports
Title
The comparative investigation of non-small cell lung tumor response at conventional and trans-bronchial intratumoral chemotherapy.
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Head
Tarasova O.N.,
Registration Date
14-12-2011
Organization
Grigor'ev Institut for Medical Radiology
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Subject of investigation - macromorphological and micromorphological characteristics of therapeutic pathomorphosis of the tumor: tumor cell death, cell density inside tumor, structure of stroma and vessels of the tumor, chemotherapy-induced side effects. Objectives - To compare the rates of the regression of malignant lung tumor between the conventional, intravenous and intratumoral, transbronchial administration of the antitumor drugs. Research methods and equipment - a conventional clinical and morphological analysis, endoscopy, X-ray, Computer Tomography, hematological, biochemical, histological analysis and electron microscopy. Results: The medical case histories of non-small cell lung cancer patients were analyzed for the comparative evaluation of two chemotherapeutic schemes: gemcitabin plus cysplatinum versus paklitaxel plus cysplatinum. The chemotherapy using gemcitabin plus cysplatinum caused a higher outcome of the toxic effects of grade II and III, i.e. trombopenia, anemia, leucopenia, nausea, vomiting and diarrhea. For the chemotherapy with paklitaxel plus cysplatinum the sensor neuropathia, the lesser grade of hematologic toxicity and gastrointestinal side effects (mainly, grade I and II) were observed. The severity of the side effects had an additive pattern and increased from the first to the fourth course of the treatment. The individual features of cell ultrastructure and their specific characteristics were detected in non-small cell lung cancer (adenocarcinoma). It was shown that the total efficacy of the scheme using gemcitabin (48,9 %) was higher than that of with paklitaxel (44,1 %). Areas of application: medicine, oncology.
Product Description
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Артамонова Н.О.
Кононенко О.К.
Лукашова О.П.
Насонова А.М.
Паскевич О.І.
Спузяк Р.М.
Тарасова О.М.
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2020-04-02
