Registration Number
0211U009521,
0107U000060
, R & D reports
Title
New approaches to the synthesis of metalloproteinase inhibitors for treatment of diseases connected with high activity of enzymes and investigation of their properties.
popup.stage_title
Head
Staninets Vasilii Ivanovich,
Registration Date
26-12-2011
Organization
Institute of Organic Chemistry National Academy of Sciences of the Ukraine
popup.description2
To create novel inhibitors of zinc-containing proteinase enzymes, methods for the synthesis of heterocyclic compounds containing functional groups (amino-, hydroxyl-, hydroxyimino-, thioxo-, carboxy-, etc), which are able to form donor-acctptor bonds with Zn(II) ions, have been developed. Among the compounds synthesized, substances hav been found which form stable complex compounds with Zn(II) salts in aqueous solution and separate out in crystalline form from their solutions. Forming coordination compounds with zinc-containing proteinase enzymes and bonding zinc ions that are at active site, such substances can act as efficient inhibitors of these enzymes and can be used as drugs for the treatment of cancer, infections and other diseases with are connected with high activity of zinc proteinases.
Product Description
popup.authors
Бентя Антон Валентинович
Больбут Андрій Вікторович
Васькевич Руслан Іванович
Зборовський Юрій Леонідович
Нестеренко Олександр Михайлович,
Орисик Віктор Васильович
Савицький Павло Володимирович
Сергучев Юрій Олексійович
Чубарук Наталія Григорівна
popup.nrat_date
2020-04-02
