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Information × Registration Number 0213U002188, 0112U007642 , R & D reports Title Development and application of target oriented methods for initial screening of molecules as potencial antibacterial agents. popup.stage_title Head Tukalo Mykhaylo, Доктор біологічних наук Registration Date 17-01-2013 Organization Institute of Molecular Biology and Genetics of NASU popup.description2 The two promising molecular targets for the development of new antibacterial drugs have been revealed: prolyl-tRNA synthetase Enterococcus faecalies and leucyl-tRNA synthetase Mycobacterium tuberculosis. The features of the spatial structure of the binding sites of targets (leucyl and prolyl-tRNA synthetases pathogenic organisms) have been investigated, the receptor-based virtual screening was performed and results for the 100 000 organic compounds have been obtained. About 500 quinoline derivatives have been synthesized to enrich the compound library by substances with potential antibacterial activity. The methods of expression and obtaining of recombinant target enzymes for biochemical tests and methods of in vitro tests to determine the activity of studied organic compounds have been developed.5481 Product Description popup.authors Яpемчук Ганна Дмитрівна 4. Кpикливий Iван Андрійович Бджола Володимир Григорович Бояршин Костянтин Сергійович Волинець Галина Петрівна Грищенко Андрій Анатолійович Гудзеpа Ольга Йосипівна Коваленко Оксана Петрівна Лукашов Сергій Степанович Ярмолюк Сергій Миколайович popup.nrat_date 2020-04-02 Close