Registration Number
0213U003084,
0110U002200
, R & D reports
Title
Study some multipotent stromal and hematopoietic stem cells interaction mechanisms and lymphocyte differentiation processes depending on their properties
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Head
Butenko Gennadiy Mikhailovych,
Registration Date
18-01-2013
Organization
Institute of genetic and regenerative medicine Acad.Med.Sci. of Ukraine
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The different types of multipotent stromal cells isolated by optimized cell culture methods interact with hematopoietic cells of fetal liver in vitro via membrane cell-cell contacts and secretion of active humoral factors. It has a marked but often differently directed effect on humoral and cellular immunity depending on cell number, their origin, their initial functional state, the influenced cell types and particularities of lymphocyte differentiation stages within immune response formation. Contact interaction has main impact in the process of activation and differentiation of lymphocytes but humoral influence provides a positive effect during the negative consequences abrogation in the realized model of prolonged stress. It manifested by a rapid healing of gastric ulcers and restoration of activity of the immune system, which makes the MSCs therapy a promising long-term stress reaction treatment in a future.
Product Description
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Галицька С.М.
Зубов Д.О.
Малишева О.О.
Нікольська В.В.
Нікольський І.С.
Савінова В.О.
Тарануха Л.І.
Федорчук О.Г.
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2020-04-02
