Registration Number
0214U000538,
0111U002890
, R & D reports
Title
To study the influence of low molecular weight fractions of blood autologous serum on regeneration processes in complex medicamentous and surgical treatment of persistent erosions and torpid corneal ulcers at degenerative and dystrophic corneal
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Head
Drozhzhina Galina I.,
Registration Date
19-03-2014
Organization
The Filatov Research Institute of Diseases and Tissue Therapy
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The effect of low molecular weight fractions of auto blood serum on regeneration processes in complex medical and surgical treatment of persistent epithelial defects and torpid ulcers at degenerative and dystrophic diseases of the cornea was studied (neurotrophic keratopathy , herpetic keratitis , keratoconjunctivitis sicca , hereditary stromal corneal dystrophy, keratoconus ) . The diagnostic model "classification tree" for determining the severity of corneal lesions in individual patients was proposed (presence of persistent epithelial defect, torpid ulcers and disorders of cornea regeneration after keratoplasty), that allows up to 95,4% to determine the severity of the disturbance of the corneal regeneration (Patents of Ukraine № 78192 and 78193). Application of auto blood serum in complex medical treatment of corneal persistent epithelial defects and torpid ulcers increases the regenerative capacity of the cornea, which is confirmed by prevalence in cytograms epithelial cells of the cornea with the expression of cytokeratin 3 (70%) or equal ratio of the epithelial cells of the cornea and conjunctiva (50% expression of cytokeratin 3 and 50% expression of cytokeratin 19), improving the tactile sensitivity of the cornea in 40.5 % of cases, reduce period of corneal epithelisation at persistent epithelial defects - 6,2 days, at torpid ulcers - 8.7 days. On the developed model of neurotrophic keratitis (Patent of Ukraine № 66507) was found that the optimal is subconjunctival injections of the suspension culture of limbal corneal epithelial cells (Patent of Ukraine № 65507) in a dose of 1 million. in 0.2 ml. nat. solution, as evidenced by the fast regeneration of corneal tissue. The method of prevention of the development of cataracts in patients with keratitis was worked out (Patent of Ukraine № 62795).
Product Description
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Пампуха Володимир Миколаєвич
Іванова Ольга Миколаївна
Івановська Олена Володиміровна
Артьомов Олександр Валентинович
Віт Валерій Вікторович
Гайдамака Тетяна Борисівна
Головченко Валентина Григорівна
Гутник Віктор Миколайович
Драгомірецька Олена Іванівна
Дрожжина Галина Іванівна
Думброва Наталія Євгенівна
Коган Борис Михайлович
Коломійчук Сергій Георгієвич
Лівшиць Людмила Аврамівна
Леус Микола Федорович
Нестерук Наталія Іванівна
Пономарчук Валерый Сесенович
Тройченко Людмила Федорівна
Усов Володимир Якович
Храменко Наталія Іванівна
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2020-04-02
