Registration Number
0214U005951,
0110U004761
, R & D reports
Title
Development of new therapeutic approaches for chronic pain treatment with little side effect, which based upon genetic regulation of dynamic properties of spinal cord glutamate receptors.
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Head
Voitenko Nana Volodymyrivna,
Registration Date
30-12-2014
Organization
Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine
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Molecular mechanisms of change in calcium conductance of AMPA receptors, which are expressed in extrasynaptic membrane of neurons substance gelatinosa dorsal horn of the spinal cord of rats with peripheral CFA-induced inflammation have been sduded. It is shown that the trafficking extrasynaptic Ca2+-permeable AMPA-receptor-induced inflammation in SG neurons tonic type depends on the activation of PKC?, and this PKC?-dependent trafficking may contribute to the maintenance of inflammatory pain. The method of the delivery of genetic material locally in the neurons of the lumbar spinal cord was developeded. It was found that blocking the expression of PKC? by introducing highly selective genetic material locally in the lumbar section of the spinal cord shows a significant therapeutic effect on relieving pain caused by prolonged peripheral inflammation.
Product Description
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Іванова Світлана Юріївна
Білан Павло Володимирович
Войтенко Нана Володимирівна
Вятченко-Карпинский В'ячеслав Юрійович
Гончаренко Юлія Володимирівна
Кротов Володимир Вадимович
Хомула Євген Валерійович
Черкас Володимир Петрович
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2020-04-02
