Registration Number
0214U008075,
0109U003770
, R & D reports
Title
Grounds and elaboration of cholangitis treatment methods.
popup.stage_title
Head
Kanikovsky Oleg Evgeniyovych,
Registration Date
01-07-2014
Organization
Dovganeuk Inna
popup.description2
In the research work is defined regression dependence reversibility of structural changes in the wall of the common bile duct based on multivariate mathematical planning of the experiment revealed that a very strong correlation (R2 = 0,9828) with pathological changes wall of the common bile duct are indicators of hyperbilirubinemia (t = 6.720), the diameter of the common bile duct (t = 16,786) and intraductal pressure level (t = 46,537), where t - Student test for significance of regression coefficients manifestations of cholangitis, R2 - coefficient of determination. Calculation of the factor G reversibility of structural changes in the wall of the common bile duct in accordance with the quadratic regression equation established limit irreversibility / reversibility of structural changes in the walls of the bile ducts figure 0.562. When G> 0,562 - changes in the wall of the bile duct with cholangitis wear reversible when G <0,562 - are irreversible changes that are indicative of the formation biliodyhestyvnoho anastomosis. Predictors of pancreatic intraductal hypertension in patients with chronic pancreatitis had recurrence of pain, which is insensitive to conservative measures, body mass index less than 16.3, the level of ?-amylase in the pleural or peritoneal exudate more than 1024 units., Widening to 4.7 mm and cystic transformation duct system and desytometrychni signs 248,5 HU fibrous transformation of pancreatic tissue. Using the proposed algorithm surgery cholangitis led to an increase of 17.2% share of patients in whom correction of biliary hypertension using minimally invasive technology was the ultimate way of surgical treatment (t = 2,368; p <0,05) and increased by 20% the proportion of patients with normalization of the diameter of the common bile duct within 14 days after surgery (t = 3,126; p <0,005). The application of the proposed method of forming holedohoduodenoanastomozu provides an increase of 15% of the pressure gradient between the common bile duct and the duodenum (t = 2,990; p <0,01) and a decrease of 13.3% frequency duodeno-biliary reflux (t = 2,145; p <0 , 05), compared with the known method. Use of internal and combined (inner) decompression in cysts of the pancreas with the diminishing of recurrence in 13.9% of cysts and pain to 6.8%. Pankreatoyeyunostomiya by Fray - Izbicky can reduce recurrence of pancreatic intraductal hypertension 11.1%, compared to the longitudinal pankreatoyeyunostomiyeyu in patients with obstructive and fibrotic form of chronic pancreatitis and reduce the rate of SF-36 "pain intensity" to 3,2 ± 0,19. Effectiveness of endoscopic papilosfinkterotomy nasobiliar drainage and endoscopic dilatation of the pancreatic duct increases with obstructive form of chronic pancreatitis, compared with 43.2% for fibrous. On the basis of the research program is optimized multimodality treatment cholangitis, which compared with the traditional treatment reduces by 25% the size of the lumen of the recovery period of the common bile duct (t = 2,514; p <0,02), reduces to 3 times the number of postoperative complications (t = 2,157 ; p <0,05), decreases 1.3 times term inpatient treatment (t = 4,445; p <0,001) and increases by 14% the index of quality of life EQ-5D (t = 3,071; p <0,005).
Product Description
popup.authors
Андросов Сергій Іванович
Бабійчук Юрій Валерійович
Бондарчук Олег Іванович
Гнатюк Юрій Петрович
Каніковський Олег Євгенійович
Карий Ярослав Володимирович
Мосьондз Василь Володимирович
Павлик Ігор Васильович
Рубан Микола Миколайович
Сандер Сергій Володимирович
Феджага Олег Павлович
Харчук Олексій Вікторович
popup.nrat_date
2020-04-02
