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Registration Number

0215U001147, 0114U000700 , R & D reports

Title

Development and introduction of new methods of surface enhanced Raman spectroscopy and nanomechanical spectroscopy for physical diagnostics of bioimplant and other biomedical applications.

Head

Strelchuk Viktor Vasylyovych, Доктор фізико-математичних наук

Registration Date

29-01-2015

Organization

Institute of Semiconductor Physics of National Academy of Sciences of Ukrain

Description

As the result of project effectuation, the novel methods of surface-enhanced Raman and nano-mechanical spectroscopies were developed and implemented for the physical diagnostics of bio-implants and other biomedical applications. The technology of the preparation of high efficient nanostructured SERS substrates based on the functionalized metal nanostructured substrates, colloid nanoparticles, rough surfaces and films with metal (Au, Ag) nano-islands were elaborated. The investigation of the efficiency of prepared SERS substrates with metal nanoparticles in the dependence of technological parameters of colloidal synthesis and laser ablation were performed. The interconnection between the efficiency of analytic response, optical, structural and morphological properties of nanostructured SERS substrates and their functionalization methods was found. The practical testing of the prepared SERS substrates was carried out for the following biological objects: synthesized malignant tumor cell of the breast adenocarcinoma and ovarian carcinoma. The substantial spectral differences between the benign and malignant tumors, in particular, the changes in the frequency and intensity within the spectral range of proteins, nucleic acids and lipids were found. The state certification of the Laboratory of Optical Submicron Spectroscopy were performed in the field of optical measurements the properties of liquid and solid materials.

Product Description

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Бойко М.І.
Голіченко Б.О.
Коломис О.Ф.
Кравченко С.О.
Литвин П.М.
Ніколенко А.С.
Насєка Ю.М.
Прокопенко І.В.