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Registration Number

0215U001152, 0114U001822 , R & D reports

Title

New derivatives of condensed heterocyclic compounds as topoisomerase I inhibitors, antitumor agents and reagents for the detection of nucleic acids

Head

Dubey Igor, Доктор хімічних наук

Registration Date

29-01-2015

Organization

Institute of molecular biology & genetics

Description

The series of new heterocyclic compounds, mono- and disubstituted derivatives of acridine and thioxanthone, were obtained. Their biological activity was studied in the test system of pBR322 plasmid DNA relaxation by topoisomerase I. 4,9-Disubstituted acridines were found to inhibit the enzyme at low micromolar concentrations. 6 compounds with IC50 values below 15 uM were identified, including highly active inhibitors with IC50 of 3,2 and 2,5 uM. Highly sensitive cyanine-based reagents were found for the fluorescent detection of quadruplex DNA in electrophoretic gels.

Product Description

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Ільченко М.М.
Алєксєєва І.В.
Дубей Л.В.
Костіна В.Г.
Костенко О.М.
Криворотенко Д.В.
Кузів Я.Б.
Негруцька В.В.