Registration Number
0215U002423,
0111U006497
, R & D reports
Title
New ways for diagnostic and treatment of acute pancreatitis and it's complications
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Head
Polyanskiy Igor Yuliyovich,
Registration Date
04-12-2015
Organization
Higher state educational establishment of Ukraine "Bukovinian state mediсal university"
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In work, results of experiment of mechanisms of development of acute pancreatitis and clinical peculiarity of its course in individuals with genetically determined disorders of intra-acinar trypsin inactivations have been summed up. Effectiveness of worked out diagnostic algorithms, prognosis and treatment has been proved, and this help to solve actual scientific and practical problems -improves results of treatment of patients with acute pancreatitis. It, as a whole, gives a new direction to contemporary medicine-study peculiarity of development, diagnosis, prognosis and surgical management of acute pancreatitis in individual with genetically determined predictors and its unfavorable course of disease.Distribution of R122H-polymorphism of gene PRSS1 and N34S-polymorphism of gene SPINK in population with acute pancreatitis has been studied. Worked out treatment strategy which allow well tailored option of treatment on basis of early sorting of individuals with genetically determined insufficiency of intra-acinar trypsin inactivation and higher risk of occurrence of severe course of acute pancreatitis. Implementation of proposed treatment strategy let us improve substantially result of treatment of patients with acute pancreatitis: decrease rate of occurrence of pancreatic fistulas and erosive bleeding by 25.7% and 31.0% respectively, number of repeated surgical invasion by 34.0%, frequency of postoperative complications from 31.6% to 12.5%, hospital stay in fulminant pancreatonecrosis by 8 days, mortality in patients with generalized pancreatonecrosis from 30.0% to 14.3%.
Product Description
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Іванчук Марія Анатоліївна
Андрієць Володимир Васильович
Білоокий Вячеслав Васильович
Бродовський Сергій Петрович
Войтів Ярослав Юрійович
Гирла Ян Вікторович
Гресько Михайло Михайлович
Гринчук Федір Васильович
Максим'юк Віталій Васильович
Москалюк Володимир Іванович
Полянський Ігор Юлійович
Преутесей Віталій Васильович
Тарабанчук Володимир Володимирович
Шеремет Михайло Іванович
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2020-04-02
