Registration Number
0215U003228,
0114U002849
, R & D reports
Title
Molecular-genetic factors thrombosis in patients with ph-negative myeloproliferative neoplasia who suffered from the Chernobyl accident
popup.stage_title
Head
Klymenko Serhij Victorovych, Доктор медичних наук
Registration Date
21-01-2015
Organization
State institution "National research centеr for radiation medicine of the National academy of medical sciences of Ukraine "
popup.description2
The object of study - information on clinical and hematological parameters of patients with suspected and the presence of polycythemia (SP), essential trombotsytemiyi (ET), idiopathic myelofibrosis (IMP) and myeloid neoplasms with eosinophilia (me), including those who suffered from accident at the Chernobyl nuclear power plant (NPP). Purpose - to determine the predicative value of clinical and laboratory features for the development of thrombosis in patients with Ph-negative myeloproliferative neoplasms. Research methods - clinical, hematological, statistics. It was determined that the best predictive factor for the development of thrombosis in spontaneous SP values of hematocrit is 55%, and white blood cells - 13,2 х 109 /L. The factor "hematocrit 55% (area under the curve (AUC) = 0.67) and" 13,2 х 109 leukocytes / L "(AUC = 0.66) characterized Better for predicting cardiovascular complications. Predicate on the development of cardiovascular events in patients with SP who suffered from the Chernobyl accident, was thrombocytosis 440,0 х 109 / L, which is characterized very good (AUC = 0.84) level of efficiency prediction model. The most pathognomonic for predicting thrombosis WBC ET patients without a history of radiation is 10,0 х 109/L. Efficiency marker "leukocytes 10,0 х 109 /L" for predyktsiyi spontaneous thrombosis in ET corresponds very good predictive model (AUC = 0.72). Indicator "thrombosis history" has an average level of efficiency and good predyktsiyi for future vascular events in spontaneous SU (AUC = 0.67) and EE (AUC = 0.75), respectively, as well as excellent - with radiation-associated SU (AUC = 1.00). The area under the curve ROS application of cardiac risk factors for prediction of thrombosis in patients with SP (AUC = 0.63) and IMP (AUC = 0.68) in the control group corresponds to marker average power. The efficiency factor "age over 60 years" when assessing the risk of cardiovascular events is equal to the average level in the spontaneous SU (AUC = 0.61) and radiation-associated IMP (AUC = 0.63), different levels - with radiation-associated ET (PPK = 1.00).
Product Description
popup.authors
Вербиленко Роксана Миколаївна
Міщенюк Ольга Юріївна
Неумержицька Любов Володимирівна
Шкарупа Володимир Миколайович
popup.nrat_date
2020-04-02
