Registration Number
0215U003762,
0110U003782
, R & D reports
Title
Physicochemical bases of synthesis and spectral-structural characteristics of different functional nanoscale d-metals coordination compounds with heterocyclic bioligands - hydroxyiminothiazoles, thioureas and hydroxyiminoacetates
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Head
Pekhnyo Vasyl Ivanovych,
Registration Date
24-03-2015
Organization
National Academy of Scienіses of Ukraine, Council of Productive Forces Studies of Ukraine
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The 28 new coordination compounds of transition metals (Ru, Rh, Pd, Pt, Cu, Zn) based on functionally thioureas and hydroxyiminothiazoles has been synthesized and spectral investigated. The peculiarities of these ligands in coordination complexes have been studied depending on the geometric arrangement of the donor or acceptor substituents in their molecules. The extraction-photometric methodic of determination and separation of Ru, Rh, Pd in the joint presence in model solutions of their chlorides has been developed, which is important for the processing of raw materials containing platinum metals. Antitumor effects of test compounds (Cu(II) and Pd(II) complexes based on hydroxyiminoacetates) on malignant cells have been established, making them promising to develop a new generation of anticancer drugs. It has been established that palladium complexes are nano-objects: nanotube at molar ratio M:L = 1:1 and nano fibers at M:L = 1:2 with a diameter from 25 to 100 nm. It was published in 9 articles and 6 theses.
Product Description
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Бонь Володимир Васильович
Орисик Світлана Іванівна
Репіч Гліб Геннадійович
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2020-04-02
