Registration Number
0215U007128,
0113U002148
, R & D reports
Title
To develop and improve methods of prevention and treatment of metastatic relapses of high grade bone sarcomas .
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Head
Dyedkov Anatoliy,
Registration Date
13-02-2015
Organization
Ukrainian Research Institute of Oncology and Radiology
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The object of study - 81 ill with bone sarcoma high degree of malignancy of them - 36 nemetastatychnoyi form, 45 - with developed metastases in the lungs. The aim - to improve treatment of patients with primary malignant tumors of bone and metastatic recurrence of disease by developing new and improving existing methods neoad'yuvantnoyi ad'yuvantnoyi and chemotherapy. Methods and apparatus - clinical, radiation, morphological, immunohistochemical, statistical; CT scanner Somatom 4 Plus Siemens, Germany; MRI Magnetom firm Siemens; angiograph "Televiks"; ultrasonic diagnostic apparatus 90301710 US; Microscope Nikon Esclipe 80i. Based on a retrospective analysis of patients developed distant metastases developed diagnostic algorithm for selection of patients at high risk, based on data immunohistochemical markers of prognosis and tumor localization and propagation. The method neoad'yuvantnoyi chemotherapy for patients with high risk of metastasis, which includes 3-piece circuit (methotrexate 12 g / m2, doxorubicin 75 mg / m2 cisplatin 120 mg / m2). The feature of the scheme is the use of intraarterial cisplatin administration of the assessment of the dynamics of inhibition of neovascularization of the tumor, which is the main component in the characterization of therapeutic pathomorphosis. Developed second line chemotherapy for the treatment of bone metastases sarcomas - a combination of 3 drugs: carboplatin 450 mg / m2, etoposide 300 mg / m2 and ifosfamide 8 g / m2. For the developed and advanced techniques treated 36 patients with localized form and 45 patients with metastatic bone sarcomas in the lungs.
Product Description
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Бойчук Сергій Іванович
Ковальчук Павло Анатолійович
Костюк Віктор Юрійович
Новак Олена Милославівна
Тарасова Тетяна Олександрівна
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2020-04-02
