Registration Number
0215U008103,
0112U006943
, R & D reports
Title
Allelic polymorphism of genes involved in monogenic and complex disorders development
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Head
Livshits Ludmila Avramovna,
Registration Date
08-12-2015
Organization
Institute of Molecular Biology and Genetics
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The collection of DNA samples of the patients with allelic variants of MTHFR, F5, F2, ESR1, ADRB2, ITGB3 та CYP2C9 genes belonging to the marker panel of genetic predisposition to ischemic stroke and miscarriage at females. Diagnostic methods for these gene allelic variants analyses were designed. It was revealed that some IL10 allels were markers of genetic predisposition to ischemic stroke, and some IL10 genotypes were markers of genetic predisposition to miscarriage. It was shown that some homozygous IL6 и ESR1 gene allels might be genetic markers of successful gestation at first trimester. The methods for CYP21A2gene /CYP21A1P pseudogene and SMNII gene analyses were designed.
Product Description
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Грищенко Н.В.
Кравченко С.А.
Нечипоренко М.В.
Пампуха В.М.
Соловйов О.О.
Татарський П.Ф.
Чернушин С.Ю.
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2020-04-02
