Registration Number
0216U002932,
0116U007769
, R & D reports
Title
Collagen peptides derived from Antarctic fish scales as a basis for the creation of means preventive medical action on the development of obesity and the study of mechanisms of action
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Head
Savchuk Olexiy,
Registration Date
27-12-2016
Organization
Taras Shevchenko Kiev University
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As a result of the research was optimized method for extracting collagen from fish scales Antarctic region, which has reduced the time it is received until three days and did not affect the final product yield. Results disc polyacrylamide gel electrophoresis in the presence of sodium dodecyl sulfate indicate the purity of extracted collagen, and it belongs to the first type of collagen. In further studies were chosen conditions for enzymatic hydrolysis of collagen derived fraction and low molecular weight fragments of 2 to 26 kDa. It was the influence of these fragments to the development of obesity on the model of high diet in rats. According to the obtained results, fragments of collagen extracted from fish scales Antarctic region by their oral administration reduced the amount consumed per day meal, accompanied by a corresponding decrease in body weight and body mass index animals compared to the corresponding figures for rats who were only on high-calorie diet which indirectly may indicate the ability of collagen fragments affect the feeling of fullness. It was found a modulating effect of oral low-maintenance solution collagen fragments in a number of parameters (blood glucose, glycosylated hemoglobin and insulin), considered as informative markers of insulin resistance state. The introduction of rats that were on high-calorie diet solution of low molecular weight collagen fragments helped normalize the activity of key enzymes of antioxidant protection and improved cytokine profile.
Product Description
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Вовк Т.Б.
Галенова Т.І.
Ракша Н.Г.
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2020-04-02
