Registration Number
0216U003008,
0111U006259
, R & D reports
Title
New heterocyclic compounds - effective sources of biologically-active substances, fluorescent probes, modifiers of supramolecular objects
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Head
Khilya V.P.,
Registration Date
11-01-2016
Organization
National Taras Shevchenko University of Kiev
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Report : 203 p., 228 рiсt., 36 tаbl., 1 addition, 173 references. Research object: nitrogen-, oxygen- and sulfurcomprising geterosystems. Work aim: The development and improvement of preparative methodes and methodics of synthesis of novel geterocyclic compounds for making of novel bioregulators of widespread-spectrum of range, novel photosensitive and fluorescent materials. Research methodes: Methodes of synthesis of model organic substances, geterocyclic substances; NМR-, IR-, UV-, fluorescent spectroscopy; mass- and chromatomass-spectroscopy; methodes of synthesis under high pressure and inert atmosphere; XR- and elemental analysis. The common approaches to the synthesis of derivatives of S-, N-, O-containing heterosystems were developed. A namber of original methods of synthesis of thiolane, izothiochromane, benzothiazepine and benzoxathiepine, 2- aminopirroline and thiophene based on the known alkylation, acylation, condensation, electrophilic and nucleophilic substitution reactions; the synthetic methodes of spirocondenced systems based on pyridine, pyrazine, pyrimidine, isothiazoline; 1,3-disubstituted pyrrolidine-2,5-diones (potential inhibitors of the protein InhA) based on the Michael reaction of maleimides with nucleophilic heterocycles were developed. The namber of 1-aminoizoindole derivatives and its analogs were obtained by reactions of dienophiles in a homogeneous and structured environment and by rearrangement of condensed isoindoles; azolo[a]pyridines and azolo[b]isoquinolines - by reactions of g-halo-a,b-unsaturated acid derivatives and 1,3-diazoles; functionalized azoles and azines - by reactions of 2- hetaryl-2-(tetrahydro-2-furaniliden)acetonitrile; pyrido[2,3-d]pyrimidine and azolo[b]pyridines - by reaction of 5-formyl-1,3-dimethyluracile with electron-enriched aminoheterocycles. The use of Me3SiCl in Biginelli condensation and synthesis -aminofosfonovyh acids was studied. Some methods of the synthesis of natural isoflavones and their heteroanalogs; synthetic approaches to the preparation of chromones and 2H-chromenes - tyrosine kinase receptor activators were developed. The synthesis and study of physicochemical properties of modified coumarines, neoflavones and isocoumarine derivatives; the modification of pharmacophore heterocycles with amino acid fragments was implemented. The results of SRW were applied: into subjects of Chemical department of Taras Shevchenko National University of Kyiv.
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Єгорова Т.В.
Бійцева А.В.
Бойко О.М.
Горбуленко Н.В.
Кіндер Т.Д.
Кисіль А.І.
Левков І. В.
Любчук Т.В.
Манойленко О.В.
Матвіюк Т.В.
Москвіна В.С.
Пласконь А.С.
Потіха Л.М.
Тарасюк Т. М.
Хиля В.П.
Цапко М.Д.
Шилін С.В.
Шишкіна О.О.
Шокол Т.В.
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2020-04-02
