Registration Number
0217U000504,
0114U001202
, R & D reports
Title
Identification of clinical and diagnostic features of type 1 diabetes mellitus, depending on the variant of the disease
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Head
Khyzhnyak Oksana Olegovna,
Registration Date
08-02-2017
Organization
State Institution "V. Danilevsky Institute for Endocrine Pathology Problems National Academy of Medical Sciences of Ukraine"
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Object of study: clinical chemistries, genetic markers in patients with diabetes mellitus (DM) 1 and 2 diabetes, slowly progressive autoimmune diabetes of adults (PPADD). The aim of the study: to identify differentiated approaches to complex treatment of patients with type 1 diabetes motivated to study features of manifestation and evolution of clinical symptoms, indicators of cellular and humoral immune function insulin-prodused analysis of beta-cells of the pancreas, depending on the version of the course and duration of the disease. Methods - clinical, biochemical, HRP, tools, genetics, statistics. In patients with diabetes mellitus type 1 does not have differences in clinical manifestation of the disease, depending on further labile or stable course. The possibility debut labile forms of the disease at any age. Option flow type 1 diabetes independent of the degree of reduction in beta-cell function. The duration of type 1 diabetes is a determining factor for the development and progression of diabetic nephropathy and peripheral polyneuropathy, a variant of the disease affects the progression of diabetic retinopathy and the severity of encephalopathy. Laboratory markers of alternative course of type 1 diabetes should be considered only average daily vibration amplitude glucose / A and tested method for determining insulin resistance in conditions of appointment of insulin therapy, the use of which revealed the presence of insulin resistance in 19.13% of patients with diabetes type 1. The changes of cellular immunity depending on the duration and course of variant type 1 diabetes. In the course of labile type 1 diabetes more likely detected antibodies to insulin. Not found differences in the accumulation of family diabetes mellitus type 1 and 2 relatives of individuals with different clinical variants course of type 1 diabetes. Determined the presence of significant differences in the distribution of genotypes of C1858T gene PTPN22, A49G gene CTLA4 and KCNJ11 E23K gene among patients with labile and stable course of type 1 diabetes. Established in the absence of a number of patients with diabetes type 1's ability to adequately assess their state of the characteristics of the disease. Based approaches to treat various options for type 1 diabetes. Area of application - health care.
Product Description
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Алексєєва І.
Барабаш Н.
Бурма Т.
Воропай Т.
Гавриш Т.
ГогітідзеТ.
Завадська Н.
Зайцева Л.
Захарова Г.
Манська К.
Микитюк М.
Світлова-Коваленко О.
Тихонова Т.
Ушакова Л.
Хижняк О.
Червенко О.
Штандель С.
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2020-04-02
