Registration Number
0217U006186,
0114U000244
, R & D reports
Title
The study of immunological aspects of chronic inflammatory processes of upper respiratory tract disease course
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Head
Kolyada Tatjana Ivanovna,
Registration Date
27-02-2017
Organization
State Esteblishment "Mechnikov Institute of Microbiology and Immunology of Ukrainian Academy of Medical Sciences"
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To improve the methods of immunocorrection for complex treatment of patients with chronic inflammatory processes of the upper respiratory tract, the dynamics of immunological parameters in acute and reconvalescence phases of chronic tonsillitis were studied and the comparative characteristic of immunological parameters in patients who received the standard therapy and in ones who received complex treatment with immunocorrection was carried out. The immunological criteria of the advisability of immunocorrective therapy were justified on the basis of the obtained results. The study involved 148 patients and archival data of 215 patients with chronic tonsillitis were analyzed. According to the results of the complex study of immunological, microbiological and clinical parameters in patients with chronic tonsillitis and comorbid diseases, the algorithm of choice of chronic tonsillitis treatment strategy and tactics has been developed. The use of this algorithm for further stratification of patients with a combination of chronic tonsillitis and atopic dermatitis or recurrent herpes infection allowed objectifying the indications for conservative or surgical treatment of chronic tonsillitis, to achieve a higher efficiency of immunocorrection, to reduce the number of relapses during the year. Application of the second phase of immunocorrective therapy including the systemic immunomodulator allowed to achieve significant clinical improvement on the 90th day of treatment in 41.2% of patients with a combination of chronic tonsillitis and atopic dermatitis and in 31.8% of patients with a combination of chronic tonsillitis and recurrent herpes infection. In these subgroups of patients, a decrease in the number of relapses per year in 2.5 and 1.5 times has been observed, respectively, compared with a subgroup that included patients treated with conservative therapy without the second phase of immunocorrective therapy. Methods: immunological, clinical, microbiological.
Product Description
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Білозеров О. П.
Бойко А. А.
Зеленська А. Д.
Коляда Т. І.
Макаревич В. А.
Сєрова Г. О.
Тупотілов О. В.
Чуднова Т. М.
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2020-04-02
