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Registration Number

0218U001204, 0116U004755 , R & D reports

Title

Photosensitive, fluorescent and fluorine-containing biologically active peptidomimetics for the latest diagnostic and therapeutic approaches.

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Head

Komarov Igor,

Registration Date

26-01-2018

Organization

Taras Shevchenko Kiev University

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Object of research: the design and synthesis of amino acids, which are photosensitive, fluorescent, conformationally limited and / or contain fluorine-containing substituents; introduction of synthesized amino acids into the composition of known biologically active peptides by solid-phase peptide synthesis; studying the biological properties of peptides (peptidomimetiki) obtained and their pharmacological characteristics for the purpose of their use in the diagnosis and treatment of infectious diseases and cancer diseases. Purpose: design, synthesis and development of methods of use in the diagnosis and treatment of infectious diseases and cancer diseases of such peptides, which are modified by the remnants of fluorine-containing, fluorescent or photosensitive amino acids. Methods of research: organic synthesis, computer simulation, analysis by means of physical methods. The design and synthesis of new fluorine-containing, fluorescent and photosensitive amino acids was carried out. New synthesized fluorine-containing amino acids (analogues of natural amino acids - valine, leucine, isoleucine, methionine, arginine, and lysine) meet all the requirements of compounds that can be used as labels for 19F-NMR spectroscopy - have a rigid hydrocarbon skeleton monofluoroally substituted, obtained in an optically active form, Fmoc-protected for use in solid-phase peptide synthesis. The fluorescent amino acid was designed on the basis of a heterocyclic nucleus - 2-hydroxychromone, and exhibits two-band fluorescence. New photosensitive amino acids were synthesized based on spirocyclical photoconductors. The synthesized fluorine-containing amino acids have been introduced into known peptides to validate their use as labels for spectroscopic studies and diagnostics.

Product Description

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Комаров І.В.
Пивоваренко В.Г.
Радченко Д.С.

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2020-04-02