Registration Number
0218U001204,
0116U004755
, R & D reports
Title
Photosensitive, fluorescent and fluorine-containing biologically active peptidomimetics for the latest diagnostic and therapeutic approaches.
popup.stage_title
Head
Komarov Igor,
Registration Date
26-01-2018
Organization
Taras Shevchenko Kiev University
popup.description2
Object of research: the design and synthesis of amino acids, which are photosensitive, fluorescent, conformationally limited and / or contain fluorine-containing substituents; introduction of synthesized amino acids into the composition of known biologically active peptides by solid-phase peptide synthesis; studying the biological properties of peptides (peptidomimetiki) obtained and their pharmacological characteristics for the purpose of their use in the diagnosis and treatment of infectious diseases and cancer diseases. Purpose: design, synthesis and development of methods of use in the diagnosis and treatment of infectious diseases and cancer diseases of such peptides, which are modified by the remnants of fluorine-containing, fluorescent or photosensitive amino acids. Methods of research: organic synthesis, computer simulation, analysis by means of physical methods. The design and synthesis of new fluorine-containing, fluorescent and photosensitive amino acids was carried out. New synthesized fluorine-containing amino acids (analogues of natural amino acids - valine, leucine, isoleucine, methionine, arginine, and lysine) meet all the requirements of compounds that can be used as labels for 19F-NMR spectroscopy - have a rigid hydrocarbon skeleton monofluoroally substituted, obtained in an optically active form, Fmoc-protected for use in solid-phase peptide synthesis. The fluorescent amino acid was designed on the basis of a heterocyclic nucleus - 2-hydroxychromone, and exhibits two-band fluorescence. New photosensitive amino acids were synthesized based on spirocyclical photoconductors. The synthesized fluorine-containing amino acids have been introduced into known peptides to validate their use as labels for spectroscopic studies and diagnostics.
Product Description
popup.authors
Комаров І.В.
Пивоваренко В.Г.
Радченко Д.С.
popup.nrat_date
2020-04-02
