Registration Number
0218U002107,
0112U004217
, R & D reports
Title
Design and synthesis of specific G-quadruplex ligands and study of their interaction with quadruplex DNA structures
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Head
Dubey Igor, Доктор хімічних наук
Registration Date
17-01-2018
Organization
Institute of Molecular Biology and Genetics of NASU
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The structures and methods of synthesis of numerous ligands of quadruplex DNA (G4) were proposed. The study of their biological activity revealed efficient telomerase inhibitors with antitumor activity in vitro at nanomolar concentrations (EC50=50-700 nM). Mechanisms of ligand-G4 interaction were studied using biophysical methods and molecular modeling. The "structure-activity" relationship was analyzed to find factors determining the biological activity of compounds. The obtained data are the basis for designing efficient inhibitors and antitumor agents. New reagents for the fluorescent detection of G4 DNA were developed.
Product Description
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Ільченко Микола Миколайович
Алексеєва Інна Володимирівна
Дубей Лариса Василівна
Костіна Валентина Григорівна
Криворотенко Дмитро Валентинович
Кузів Ярослав Богданович
Лисенко Надія Антонівна
Негруцька Валентина Володимирівна
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2020-04-02
