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Information × Registration Number 0218U002177, 0116U007672 , R & D reports Title Development of innovative medical substances for overcoming metabolic syndrome popup.stage_title Head Tolmachev Andrij, Доктор хімічних наук Registration Date 30-01-2018 Organization Taras Shevchenko Kiev University popup.description2 Оbject of research: Organic heterocyclic compounds as potential medicinal products. Three FFA1 receptor chemical agonists: EN300-183708 and Z1768420549 have been studied which have excellent FFA1 selectivity (GPR40) compared to other free fatty acid receptor panels (FFA2 / GPR43, FFA3 / GPR41 and FFA4 / GPR120). Biological testing of experimental compounds in glucose tolerant test on intact animals demonstrated a pronounced hypoglycemic effect of both drugs in vivo. The study of acute toxicity of the drug Z1768420549 revealed the presence of hepatotoxic effects - at the use of doses of 10 mg / kg and higher was observed increased activity of liver enzymes in serum, with the use of doses of 25 mg / kg and the highest was observed violation of blood formula and increase the weight of the liver. Product Description popup.authors Бойко О.М. Бориско П.О Желуденко М.В Зозуля С.А Кондратюк А.С Наумчик В.С Пішель І.М Толмачов А.О. popup.nrat_date 2020-04-02 Close