Registration Number
0218U003032,
0115U002969
, R & D reports
Title
Study of enzymocytochemical and immunocytological features of hematopoietic progenitor cells at the different types of hemoblastosis
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Head
Gluzman Danylo Fishelevych, Доктор медичних наук
Registration Date
12-01-2018
Organization
R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology
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It was demonstrated that the leukemic stem cells in chronic phase (CP) of chronic myelogenous leukemia (CML) possess the morphological features of lymphocyte-like cytochemically inert cells with immunophenotype of the pluripotent hemopoietic cells (CD34+CD38-). In acceleration phase, the low differentiated progenitor cells acquire the capacity for self-renewal and express CD38 antigen. In blast crisis (BC) phase of CML, CD34+CD38+ cells in bone marrow amount up to 20%. A fraction of these cells (up to 10%) demonstrates the minimal features of lineage commitment. The increased count of CD34+ progenitor cells at the stage of transition from CP to BC CML is associated with worse response to tyrosine kinase inhibitors and may be considered as the criterion of treatment efficacy. The estimation of blast cell percentage and accounting for the type of myelomonocytic leukemia is of importance for the distinct identification of the groups of patients with high probability of the development of the acute myeloid leukemia who require the specific age-adjusted therapy
Product Description
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Іванівська Тетяна Степанівна
Глузман Данило Фішелевич
Кірієнок Галина Валентинівна
Коваль Стелла Володимирівна
Петрусь Наталія Олександрівна
Поліщук Альона Станіславівна
Скляренко Лілія Михайлівна
Українська Наталія Іванівна
Швидка Марина Сергіївна
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2020-04-02
