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Information × Registration Number 0218U006036, 0117U003610 , R & D reports Title Synthesis and analysis of new structural analogues of arginine and canavanine as components of metabolic antitumor therapy popup.stage_title Head Stasyk Oleh Volodymyrovych, Кандидат біологічних наук Registration Date 07-03-2018 Organization Institute of cell biology, National Academy of Sciences of Ukraine popup.description2 According to the lowest affinity for recombinant arginase of human 1 in silico, two heterocyclic analogues of arginine are selected. Both compounds are synthesized and purified, their structure and elemental composition are confirmed. Successfully completed the initial stages of synthesis of the analogue of arginine of plant origin, indospicin. It has been confirmed that both commercial (canavanine, homoarginine, thioarginine) and newly synthesized arginine analogues are nontoxic for tumor cells in the arginine-containing medium. It was shown that among the investigated analogues compounds with the affinity for arginyl tRNA (сanavanine and thioarginine) are cytotoxic under arginine deficiency.5481 Product Description popup.authors Вовк О.І. Курліщук Ю.В. Маєвська О.М. Сенчук О.Ю. Чернишук С.В. Шуваєва Г.Ю. popup.nrat_date 2020-04-02 Close