Registration Number
0218U007461,
0116U008928
, R & D reports
Title
Epigenetic mechanisms of physical factors action upon brain structures and homeostasis
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Head
Godlevsky Leonid Semenovich,
Registration Date
18-12-2018
Organization
Odesa National Medical University
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The study was conducted on 120 Wistar rats. The purpose of the work was to study the peculiarities of aggressive behavior of animals under the influence of magnetic field pulses, the study of the role of the dopaminergic system of the brain in the realization of the effects of the magnetic field, and also the study of the effects of electrical stimulation (ES) of the cerebellum on convulsive activity. Methods of investigation: transcranial magnetic stimulation and ES of brain in rats, injection of pharmaceuticals. Studies have shown that aggressive behavior in rats is inhibited by transcranial magnetic stimulation and this effect is realized due to activation of dopaminergic mechanisms of the brain. The combined use of axinibine (5.0 mg/kg) and ES of the cerebellum (5 sessions) prevents the occurrence of behavioral and electrographic manifestations of convulsions in kindling rats. The obtained results are valuable for the development of methods for correction of aggressive behavior and treatment of seizures.
Product Description
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Біднюк Катерина Анатоліївна
Годлевський Леонід Семенович
Грушко Вячеслав Володимирович
Кресюн Наталія Валентинівна
Мандель Олександр Володимирович
Марченко Сергій Валерійович
Нєнова Оксана Миколаївна
Новіков Вячеслав Пантелійович
Первак Михайло Павлович
Пономаренко Андрій Іванович
Приболовець Тетяна Володимірівна
Сон ГаннаОлександрівна
Татарчук Тетяна Вікторівна
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2020-04-02
