Registration Number
0219U001056,
0115U002587
, R & D reports
Title
The synthesis of novel bioactive derivatives of azaheterocycles and study of their properties.
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Head
Brovarets V., Доктор хімічних наук
Registration Date
09-01-2019
Organization
V.P. Kukhar Institute of bioorganic chemistry and petrochemistry
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The alkylation of 4-(phenylthio)-1H-pyrazole-5-ol with the methyl ester of bromoacetic acid was studied. A series of phenylpyrazolyl sulfides that have been oxidized in sulfones have been synthesized, and the resulting esters have been tamed to the corresponding acids as potential bioactive substances. It has been found that the interaction of affordable 2-methylsulfonyl-3-ethoxyacrylonitrile with amides, their analogs and aminoazoles leads to previously unknown 4-amino-5-methylsulfonylpyrimidines and their condensed derivatives. It has been shown that the interaction of readily available tetrahloro-2-aza-1,3-butadienes with N-phenyl-1,2-cyclopentanediamine results in the regioselective annealing of cyclopentane to the 1,3,5-triazepine cycle. It was found that the acylation and sulfonylation of substituted pyrazolo[3,4-d][1,2,3]triazin-4-ones results in the destruction of the triazine cycle and the formation of new functionally substituted derivatives of pyrazole with a variety of biological activity.
Product Description
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І.Н. Яковенко
А.М. Корнієнко
А.О. Гуренко
Б.А. Демидчук
В.В. Жирнов
В.М. Прокопенко
В.С. Зябрєв
Г.П. Мруг
Е.Р. Абдурахманова
К.В. Туров
К.М. Кондратюк
М.С. Фрасинюк
О.В. Головченко
О.В. Шабликін
О.Д. Качковський
О.П. Козаченко
О.П. Мітюхін
Р.М. Виджак
С.А. Чумаченко
С.В. Ключко
С.Г. Пільо
С.Р. Сливчук
С.Я. Панчишин
Я.І. Простота
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2020-04-02
