Registration Number
0219U001243,
0116U003041
, R & D reports
Title
Pathogenesis of molecular genetic disorders of the fatty and carbohydrate metabolismin diabetes mellitus 2 types and optimization of medicine therapy
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Head
Pankiv Vladimir Ivanovich,
Registration Date
22-01-2019
Organization
Ukrainian scientifical-practical center of endocrine surgery, endocrine organs and tissues transplantation of Ukrainian Ministry of Health
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According to the results of the study, significant gender differences in genetic risk for obesity and CD2 have been identified. It is shown that the Q223R polymorphism of LEPR is closely related to the development of overweight and obesity. However, in women, the presence of the G allele (homozygotes GG and heterozygotes AG) was associated with an increase in BMI> 25, an increase in levels of LDL and C peptide. Analysis of TNF-alpha polymorphism at -308G> A site revealed differences in the frequency of genotypes GG, AG and AA due to a higher proportion of allele A among diabetic patients. Comparison of laboratory parameters in diabetic patients with different genotypes revealed that individuals with genotype GG recorded higher glycosylated hemoglobin and preprandial glucose, insulin, triglycerides and total cholesterol. This reflects the role of the IL-6 gene polymorphism in the development of hyperinsulinemia, and is believed to be resistant to insulin. The development of cardiovascular complications in patients with CD2 was associated with the EDNRB-rs5351 polymorphism but was more dependent on the duration of diabetes.5481
Product Description
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Сулаєва Оксана Миколаївна
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2020-04-02
