Registration Number
0219U005312,
0114U000932
, R & D reports
Title
Mechanisms of the functioning of the central and peripheral nervous system under normal and pathological conditions
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Head
Rodinskiy Alexander Georgievich, Доктор медичних наук
Registration Date
02-08-2019
Organization
Dniepropetrovsk State Medical Academy
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The peculiarities of the monosynaptic activity of the afferent, central, efferent link by the reflex arc under conditions of experimental ovarian dysfunction and the state of hyperreflexia with glucocorticoid dysfunction were investigated. For the first time, an increase in the excitability of the afferent link of the reflex arc during glucocorticoid dysfunction and a decrease in excitability during experimental menopause have been established. The content of neurotransmitter amino acids in the cerebral cortex and in the hippocampus against the background of thyroid dysfunction in three age groups was also studied. It is established that the increase of glutamate in the neocortex and the hippocampus of old rats, which is probably related to the excitotoxic effect relative to spatial memory and anxiety of this age group. In juvenile and young rats, on the contrary, an increase in the inhibitory neurotransmitter amino acids, serotonin and glycine, was observed, which may have led to an improvement in the protective behavior in hyperthyroidism and deterioration in hypothyroidism.
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Бєлоконь Вікторія Миколаївна
Басиста Катерина Ігорівна
Гніненко Олександр Миколайович
Гузь Людмила Василівна
Гутнік Ігор Олександрович
Демченко Олена Михайлівна
Кондратьєва Олена Юріївна
Маража Ірина Олександрівна
Мозгунов Олександр Володимирович
Мякушко Володимир Аркадійович
Писаревська Карина Віталіївна
Попова Тетяна Вікторівна
Родинський Олександр Георгійович
Ткаченко Сергій Сергійович
Чобіток Лілія Олександрівна
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2020-04-02
