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Registration Number

0219U005491, 0115U006643 , R & D reports

Title

Multiplex determination of influence of systemic and local factors on vaginal microbiocenosis

Head

Gruzevskiy Alexander Anatolyevich,

Registration Date

26-11-2019

Organization

Odesa National Medical University

Description

Using Real-time PCR there was held quantitative examination of vaginal contents of 53 women without of inflammatory-infectious process signs. Age of these women was from 18 to 52, presence of normal and conditionally-pathogenic and absence of strictly pathogenic microflora was necessary. On the base of determination of Conditionally-pathogenic microflora index (CPMI), and other direct or indirect signs of presence or absence of inflammation, next groups of examination were formed: I group - normocenosis, CPMI not less than 3 lg Genome-equivalent/sample, quantity of conditionally-pathogenic microorganisms wasn't more than 104,5, mycoplasmas were absent. II group - dysbiosis of I grade - CPMI from 3 to 1 and presence of some clinical and laboratory signs, III group - CPMI less than 1 lg GE/sample; valuable decreasing of common bacterial mass and Lactobacillus spp., appearance of mycoplasmas and utmost constant contents of Candida.

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Грузевський Олександр Анатолійович
Дубіна Анжела Володимирівна
Шевчук Ганна Юріївна