Registration Number
0219U102160,
0116U008795
, R & D reports
Title
Heterocatalytic hydrogenation - an effective approach to biologically important saturated nitrogen-containing compounds with practically useful properties
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Head
Yurchenko Oleksandr O., Кандидат хімічних наук
Registration Date
20-12-2019
Organization
Institute of Organic Chemistry NAS of Ukraine
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Object of study - functionalized heterocyclic compounds ( pyrrole, condensed nitrogen cycles) and maсrohetero (carbo) cyclic compounds, homo- and heterogeneous hydrogenation catalysts. Objective: implementation of a technologically efficient, environmentally sound and economically cheap method of making functionalized heterocyclic (pyrrolidine, piperidine) and maсrohetero (carbo) cyclic compounds, based on the use of appropriate technology catalytic hydrogenation of available substrates. Research methods - organic synthesis, elemental analysis, spectral methods (IR, NMR spectroscopy, mass spectrometry and chromatography), X-ray analysis. An efficient method of hydrogenation of substituted pyrrole-3-carboxylates in the presence of 10% Pd / C catalyst was developed. It is established that the course of the reaction of the hydrogenation of the pyrrole cycle at 40 ° C for 20 h is accompanied by a complete conversion of the starting compounds, is characterized by high stereoselectivity and leads to a diastereomeric mixture of N-Boc-protected pyrrolidine-3-carboxylates, which 1H NMR spectra and chromatomas spectra were 84-87% and 13-16%, respectively. Convenient and preparative methods of catalytic hydrogenation of quinolines have been developed, which allow to obtain tetrahydroquinolines without using special purification methods.
Product Description
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Vovk Mykhailo V.
Kemskii Serhii V.
Chaikovska О.О.
Cherenok Sergiy O.
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2020-04-02
