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Information × Registration Number 0220U001113, 0117U000276 , R & D reports Title Investigate the immediate and long-term effects of splenectomy in hairy cell leukemia and chronic lymphocytic leukemia complicated by immune cytopenias to optimize treatment popup.stage_title Head Yevstakhevych Iror Yosyfovych, Registration Date 27-01-2020 Organization LVIV RESEARCH INSTITUTE OF BLOOD PATHOLOGY AND TRANSFUSIONAL MEDICINE popup.description2 A retrospective analysis of the efficacy of splenectomy in 30 patients with GDL and 41 patients with CLL was performed. Splenectomy in patients with HIV, performed in connection with splenomegaly and severe cytopenia, ineffectiveness of previous treatment, directly leads to complete clinical-hematological remission (elimination of cytopenia, disappearance of hairy cells in peripheral blood in 80% of patients) to partial remission. The median undue survival (event - relapse or death from disease) of patients with GDL who underwent splenectomy was 53 months, and 5 and 10-year survival was achieved in 45% of patients, 20 years in 35%. Splenectomy was effective in 93% of CLL patients. The worst long-term results of splenectomy were observed in CLL patients complicated by autoimmune hemolytic anemia and immune thrombocytopenia at the same time. Median overall survival was 49.5 months. Indications for splenectomy in chronic lymphoid neoplasia are massive splenomegaly, abdominal discomfort, concomitant autoimmune hemolytic anemia and / or immune thrombocytopenia, regional portal hypertension, hyperplenism, ineffectiveness of cytostatic disease, cytostatic disease. Product Description popup.authors Інденко Ф.П. Бардах І.Б. Запотоцька Л.М. Книш О.В. Семерак М.М. Чабан В.Є. popup.nrat_date 2020-04-02 Close