Registration Number
0220U001113,
0117U000276
, R & D reports
Title
Investigate the immediate and long-term effects of splenectomy in hairy cell leukemia and chronic lymphocytic leukemia complicated by immune cytopenias to optimize treatment
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Head
Yevstakhevych Iror Yosyfovych,
Registration Date
27-01-2020
Organization
LVIV RESEARCH INSTITUTE OF BLOOD PATHOLOGY AND TRANSFUSIONAL MEDICINE
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A retrospective analysis of the efficacy of splenectomy in 30 patients with GDL and 41 patients with CLL was performed. Splenectomy in patients with HIV, performed in connection with splenomegaly and severe cytopenia, ineffectiveness of previous treatment, directly leads to complete clinical-hematological remission (elimination of cytopenia, disappearance of hairy cells in peripheral blood in 80% of patients) to partial remission. The median undue survival (event - relapse or death from disease) of patients with GDL who underwent splenectomy was 53 months, and 5 and 10-year survival was achieved in 45% of patients, 20 years in 35%. Splenectomy was effective in 93% of CLL patients. The worst long-term results of splenectomy were observed in CLL patients complicated by autoimmune hemolytic anemia and immune thrombocytopenia at the same time. Median overall survival was 49.5 months. Indications for splenectomy in chronic lymphoid neoplasia are massive splenomegaly, abdominal discomfort, concomitant autoimmune hemolytic anemia and / or immune thrombocytopenia, regional portal hypertension, hyperplenism, ineffectiveness of cytostatic disease, cytostatic disease.
Product Description
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Інденко Ф.П.
Бардах І.Б.
Запотоцька Л.М.
Книш О.В.
Семерак М.М.
Чабан В.Є.
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2020-04-02
