Registration Number
0220U102429,
0117U000476
, R & D reports
Title
To investigate some mechanisms of pathogenesis and risk factors for the development of autoimmune ophthalmopathy in order to optimize its treatment.
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Head
Terechova Galyna M., Кандидат медичних наук
Registration Date
13-03-2020
Organization
State Institute "V.P. Komissarenko Institute Of Endocrinology And Metabolism of The National Academy of Medical Science of Ukraine"
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Research object: risk factors for the development and long-term outcomes of treatment of Graves' orbitopathy (GO). Aim: to optimize the algorithm for diagnosis, treatment and prevention of GO based on the analysis of risk factors and individual mechanisms of pathogenesis of GO. Methods:questionnaire,clinical and ophthalmic examination, orbital ultrasonography, hormonal, immunoenzyme, biochemical studies. Results: Long-term outcomes of combined treatment in patients with GO in combination with Graves' disease (GD) were analyzed. 54 % of patients with GD, regardless of the presence of GO, had a pronounced selenium (Se)deficiency. In patients with Graves' disease complicated by GO, a significant selenium deficiency was observed in 50 % of patients. In patients with Graves' disease without GO, a significant selenium deficiency was observed in 69 % of patients. No significant difference in selenium levels between groups of patients was observed (P?0,05). Thus, it is possible to assume that Se deficiency is not a critical factor in the development of GO in Graves' disease. Selenium deficiency was not observed in 34% of patients with GD and GO, so prescribing selenium to patients with GO is impractical without individual control of selenium levels. During pulse therapy with methylprednisolone, the manifestations of orbitopathy decreased while selenium deficiency deepened. Vitamin D deficiency was found to occur in all patients with GD, and in patients with GO, 25(OH)D levels were significantly lower than in patients without GO (P?0,05). A reliable inverse linear relationship (dependence) of the TRAb levels with the levels of 25(OH)D was established in the general group of patients with GO (r =-0,53; P<0,05). The scheme of treatment of active GO with the use of selenium and vitamin D was developed elaborated. Application domain: endocrinology, ophthalmology, family medicine.
Product Description
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Buldygina Yuliya V
Klochkova Viktoria M
Strafun Lesya S
Terechova Galyna M.
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2020-04-01
