Registration Number
0221U100280,
0118U003769
, R & D reports
Title
To investigate the role of the allelic polymorphism of the glutathione-S-transferase genes of the classes P1 (GSTR1), T1 (GSTT1) and M1 (GSTM1) and other factors in the development of bronchoobstructive disorders in children living with radioactive contaminated territories
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Head
Stepanova Eugenia I., Доктор медичних наук
Registration Date
04-01-2021
Organization
State Institution "National Research Centre For Radiation Medicine of National Academy of Medical Sciences of Ukraine"
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Object of research: mechanisms of adverse effects in the bronchopulmonary system in children - residents of radioactively contaminated areas (RСА) and elucidation of the interaction of adverse environmental factors and genetic components in their implementation. Purpose: to determine the contribution of polymorphism of GST1, GSTT1, GSTM1 genes encoding GST, biochemical activity of glutathione-S-transferase, medical-biological, environmental adverse factors in the pathophysiological mechanisms of bronchial hyperreactivity and to establish their significance for predicting risk formation. children - residents of RСА. Research methods: clinical, biochemical, instrumental, molecular genetic, statistical. Results and their novelty. Studies of the bronchopulmonary system have shown that in children - residents of RСА, a decrease in bronchial patency is associated with the intensity of POL in the serum and a decrease in glutathione transferase activity. The presence of deletion polymorphisms of the GSTT1 and GSTM1 genes is associated with the intensification of LPO processes, and the mechanism aimed at compensating for this adverse phenomenon by AOS is catalase activation. Among the adverse factors that increase the risk of developing bronchoobstructive disorders and the likelihood of their implementation in the form of asthma in children, the leading role is played by hereditary predisposition to asthma, fetal development, exudative catarrhal diathesis, allergies and frequent respiratory diseases from the first months of life. The concept of the role of hereditary factors, allelic polymorphism of GSTT1, GSTM1, GSTR1 genes and adverse environmental conditions in the development of bronchoobstructive disorders and the risk of their implementation in the form of asthma in children - residents of RСА. Implementation: 7 articles, 5 abstracts, 1 patent, 1 new technology, 1 information letter, 2 implementation acts. Field of application - radiation medicine, pediatrics.
Product Description
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Aliokhina Svitlana M.
Vdovenko Vitaliy Yu.
Zygalo Viktor M.
Kolpakov Igor Ye.
Poznysz Viktoriya A.
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2021-01-04
