Registration Number
0221U101529,
0120U102209
, R & D reports
Title
Interaction of operated nanobiocomposite with model systems of different degree of sensitivity and aggressiveness of the cancer process (№ 55/20-Н)
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Head
Chekhun Vasyl F., Доктор медичних наук
Registration Date
22-01-2021
Organization
R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology National Academy of Sciences of Ukraine
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In vitro on 10 lines malignantly transformed cell lines of different histogenesis we investigated cytotoxic activity and antiproliferative action of nanobiocomposite, that contains nanoparticles of ferromagnetic and lectin. Found that nanobiocomposite has a greater cytotoxic effect compared to lectin on the cell of pancreas carcinoma (Mia-Рa-Сa-2 and Panc-I cell lines), hormone-dependent breast adenocarcinoma cells (MCF-7 line), hormone-sensitive and hormone-resistant prostate cancer cells (LNCaP and Du-145 lines) and human melanoma cells (WM 451 line). IC50 of nanobiocomposite for Mia-Pa-Ca-2, Panc-I, MCF-7 LNCaP, Du-145 and WM 451 cell lines were is 40 - 70% lower than than IC50 after the action of lectin on these cell lines. The most significant manifestations of cytotoxic effects of nanocomposite, identified in breast and prostate cancer lines, are probably due to dysregulation of metal-containing proteins and endogenous iron metabolism. The obtained data are the fundamental basis for the study of the mechanisms of action of the nanobiocomposite on the cells of hormone-dependent malignancies
Product Description
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Didenko Gennadii V.
Lykhova Oleksandra O.
Lukianova Natalia Yu.
Cheremshenko Nadiia L.
Chekhun Vasyl F.
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2021-01-22
