Registration Number
0222U001364,
0119U000085
, R & D reports
Title
Study of the influence of ligands of Toll-like receptors on the regenerative activity of human MSCs
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Head
Kordium Vitalii A,
Registration Date
26-01-2022
Organization
Institute of genetic and regenerative medicine National Acad.Med.Sci. of Ukraine
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A model of acute inflammation of the abdominal cavity in mice was developed, the effect of different doses of MSCs on the prevention and suppression of acute inflammation was studied and a method for assessing the therapeutic activity of baseline and preconditioned various factors of MSCs was developed. Preconditioning of MSCs with hydrogen peroxide, vitamin C and LPS approximately doubles the therapeutic effect of their intraperitoneal transplantation. The method of complex assessment of the effect of a number of bacterial products on the immunomodulatory properties of human umbilical cord MSCs in vitro in the model of mitogen-induced lymphocyte proliferation has been optimized. Contact cocultivation of MSCs with peripheral blood mononuclear cells has been shown to significantly reduce mitogen-induced T lymphocyte proliferation. MSCs have been shown to have both prophylactic and therapeutic effects on cognitive impairment in mice after LPS injection. Preconditioning of MSC alpha-Interferon enhanced this effect.
Product Description
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Irodov Dmytro M.
Gorbatiuk Oksana B.
Deriabina Olena H
Kovalchuk Mariya Victorivna
Minchenko Zhanna M
Morgunov Pavlo V
Okunev Oleg V
Pikus Polina O
Pokholenko Yanina O.
Rymar Svitlana Yu.
Toporova Olena Karneliivna
Usenko Mariia Oleksandrivna
Shuvalova Nadiia Serhiivna
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2022-03-09
