Registration Number
0222U005436,
0119U102695
, R & D reports
Title
To study the importance of the factors of humoral immunity and to develop a set of criteria for forecasting the course of chronic inflammatory bowel disease
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Head
Stepanov Yurij M., Доктор медичних наук
Registration Date
30-12-2022
Organization
Ukrain Research Institute of Gastroenterology Ministry of Healthcare of the Ukraine
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As a result of the study, it was established that anemic syndrome is characteristic of patients with CKD with a severe course. Specific features of the endoscopic picture of CKD depending on the degree of severity are determined. Peculiarities of humoral immunity in patients, which depended on the activity of the disease, were studied. Multidirectional changes in the content of dietary fiber in coprofiltrate were determined, and a significant decrease in butyric acid was established in patients with severe CKD. A significant increase in the level of IgG4 in blood serum was established in patients with VK compared to HC by 2.5 times. An imbalance in the composition of the intestinal microflora was established in 100% of patients, which differs in severity. The study of IgG4-positive cells of the mucous membrane of the large intestine showed that the presence of positive cases was 2 times more common in NVC than in HC, and was more characteristic of patients with an average degree of severity of the disease. Algorithms for predicting the course and effectiveness of treatment have been developed.
Product Description
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Haidar Yurii Adolfovych
Zigalo Elvira V.
Karachinova Viktoria Anatoliivna
Klenina Ina Anatoliivna
Milostiva Dariya Fedorivna
Nedzvetska Nataliya V.
Simonova Olena V.
Stoykevich Marina V.
Titova Marina V.
Tarasova Tetyana Sergiivna
Tatarchuk Oksana M.
Fyodorova Natalja S.
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2022-12-30
