Registration Number
0223U002326,
0118U005470
, R & D reports
Title
Investigation of functional plasticity of macrophages under the conditions of application of means of chemo- and biotherapy of cancer
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Head
Didenko Gennadii V., Кандидат біологічних наук
Registration Date
15-02-2023
Organization
R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology National Academy of Sciences of Ukraine
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In vitro and in vivo studies show the absence of toxic effects of low doses of Lectin B. subtilis IIV B-7724 on the cells of the immune system of intact mice C57BL.In mice C57BL line with lung carcinoma Lewis shows the antimetastatic efficiency of different modes of lectin injection against the background of primary tumor growth (mono -mode, combination with chemotherapy). This effect is largely due to changes in the functional activity of macrophages.In mice with tumors that did not receive treatment, the macrophages of M2 macrophages were prevailed.The use of lectin B. subtilis IMV B-7724 (both in mono-mode and in combination with cisplatin) ensured the preservation of functional activity of macrophages and contributed to their polarization in the direction of M1. The most pronounced antitumor effect was observed provided that combined use of chemo and immunotherapy.
Product Description
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Bazas Volodymyr M
Бережна Нінель Михайлівна
Boyko Ivan I.
Verbinenko Natalia M.
Voeykova Iryna M.
Hetman Kateryna I.
Karaman Olha M.
Koval Elizaveta V.
Kokhanivska Lyubov M.
Kruts Olena O.
Lukіanova Elizaveta D.
Symchych Tetiana V.
Tyshchenko Liudmyla M.
Trembach Lyudmyla V.
Fedorchenko Lyudmyla V.
Fedosova Nataliia I.
Khmara Valery A.
Cheremshenko Nadiia L.
Chumak Alina V.
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2023-02-15
