Registration Number
0224U001659,
0122U001801
, R & D reports
Title
Molecular design of heterocyclic compounds using multicomponent and tandem reactions for bioactivity screening and optoelectronics
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Head
Obushak Mykola D., д.х.н.
Registration Date
26-01-2024
Organization
Ivan Franko National University of Lviv
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A number of new multicomponent and tandem reactions have been developed, which make it possible to design practically useful substances by resource- and energy-saving methods. It is shown that 5-aryl-3-(2-furyl)-(2-methyl)acrylaldehydes are convenient reagents for the construction of hybrid heterocyclic structures, in particular with furo[2,3-f]isoindole and imidazo[2,1-b ][1,3]thiazol-3-one. A new multicomponent tandem [4+2] Ugy–Diels-Alder cycloaddition reaction was developed for the synthesis of furo[2,3-f]isoindoles. A new method of synthesis of phenanthridone derivatives is proposed. Methods of obtaining new hybrid structures of thiazole with 1,2,3-triazole and thiazolone derivatives were developed and compounds with antitumor activity were discovered. Methods of obtaining a number of new donor-acceptor conjugates have been developed, connected by π-spacers, and OLED devices with different emission colors have been created on their basis.
Product Description
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Horak Yuriy
Lytvyn Roman Zinoviyovych
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2024-01-26
