Registration Number
0225U000041,
(0122U200829)
, R & D reports
Title
To investigate the gender characteristics of genetically determined reproductive failure in humans
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Оптимізація алгоритму генетичних досліджень у випадку наявності гендерно нерівнозначного внеску в генез порушень процесів відтворення у людини
Head
Zastavna Danuta V., д.б.н.
Registration Date
03-01-2025
Organization
State institution "Institute of Hereditary Pathology of the National Academy of Medical Sciences of Ukraine"
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Develop and test an algorithm for selecting criteria for assessing the gender predisposition of genetically determined human reproductive losses
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The obtained results allow us to argue the extreme relevance
of the multi-level study of genome structures involved in the mechanisms
of self-reproduction of the human population. We defend the statement
that classical karyotyping is the gold standard in the system of
evaluating the biology of reproduction. A correctly selected complex of
cytogenetic, molecular genetic and molecular cytogenetic studies allows
us to verify the genetic component in the genesis of male infertility as
accurately as possible. Among the possible epigenetic factors of
disorders of spermatogenesis processes, we consider the features of
follicle-stimulating and androgenic hormone receptors. We defend the
statement that epigenetic changes in spermatozoa under the influence of
sex hormones can affect the processes of gametogenesis through changes
in DNA methylation processes and gene expression. The established
association of reproductive losses of unknown genesis with the
carriership of DQ2.5 – a genotype of predisposition to celiac disease
suggests the feasibility of HLA genotyping in risk groups for
reproductive failures in order to identify the autoimmune component.
Genotyping of immunoglobulin-like receptors of NK cells (KIRs) in a
group of women with repeated failed implantations allowed us to isolate
the critical KIR-AA genotype for women. We believe that idiopathic
repeated pregnancy losses are associated with aberrant immune function
and specific loss of immune autotolerance and autoimmunity. We advocate
the need for a comprehensive assessment of the risk of hereditary
diseases in the genesis of reproductive failures in order to correctly
prevent them before conception.
Product Description
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Huleiuk Nataliia L.
Zastavna Danuta V.
Lozynska Mariia R.
Sosnina Kateryna O.
Terpyliak Oresta I.
Tyrkus Marta Ya.
Tkach Iryna
Tretiak Bohdan I.
Chorna Liliia B.
Sharhorodska Yevheniia B.
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2025-01-03
