Registration Number
0225U003126,
(0122U001535)
, R & D reports
Title
Transport of ions and oxalates as a key factor in chronic kidney disease and associated pathologies
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Роль генетичного поліморфізму SCL26A6 транспортерів оксалатів та оксалат-деградувальних бактерій у патогенетичних проявах ХХН.
Head
Zholos Oleksandr V., Доктор біологічних наук
Registration Date
22-05-2025
Organization
Taras Shevchenko National University of Kyiv
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Determining the peculiarities of smooth and skeletal muscle function, myoepithelial interactions and epithelial barriers in renal dysfunction and oxalemia, in particular the role of sensory and receptor-controlled TRP channels in these processes, and to determine the effect of oxalate-degrading bacteria on the course CKD-associated pathologies.
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In light of the increasing number of kidney lesions according to WHO estimates, including due to COVID-19, studies of chronic kidney disease (CKD)-associated disorders of the cardiovascular system, digestive tract, skeletal muscles and their mechanisms at the cellular and molecular levels are becoming more relevant. Taking into account changes in ion and oxalate transport during the development of CKD, the goal of the project is to determine the features of the functioning of smooth and skeletal muscles, myoepithelial interactions and epithelial barriers under conditions of impaired kidney function and oxalemia, in particular the role of sensory and receptor-gated TRP channels in these processes, as well as to clarify the effect of oxalate-degrading bacteria on the course of CKD-associated pathologies. Since we have shown that a TRPM8 channel agonist improves the recovery of injured muscle function (Soroka V.M., 2015-2020), these studies were continued in the context of the relationship between the pathogenesis of CKD and skeletal muscle injury. Mechano- and osmo-sensitive TRPV4 ion channels, whose role in the regulation of vascular tone, intestinal and uterine contractility was shown by the authors of the project (Melnyk M., Moroz O., Zholos A., 2017-2020), may mediate changes that occur in smooth muscle cells (SMC) under conditions of disruption of the epithelial layer, which is affected in oxalemia. Therefore, one of the working hypotheses of the project is a change in the functioning of the vascular, intestinal and uterine HMCs in CKD as a consequence of changes in ion transport through TRPV4 and TRPC4 cation channels, since they are, respectively, mechanosensitive and ligand-gated channels and are involved in myoepithelial interactions.
Product Description
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Bohatyrov Roman Yu.
Velmyk Viktoriia V.
Dovbynchuk Taisa V.
Korbush Mariia Yu.
Melnyk Mariia I.
Moroz Olesia F.
Nozdrenko Dmytro М.
Serhiichuk Tetiana M.
Soroka Vasyl M.
Stepanova Natalia M.
Stetska Viktoriia О.
Tolstanova Hanna M.
Fishchuk Liliia Ye.
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2025-05-22
