Registration Number
0225U003321,
(0124U004303)
, R & D reports
Title
Innovative approaches to the analysis and correction of the microbiome in the diagnosis, prevention and treatment of post-traumatic stress disorders
popup.stage_title
Розроблення новітніх біотехнологічних підходів до діагностики, профілактики та лікування ПТСР.
Head
Boyko Nadiia V., д.б.н.
Registration Date
19-06-2025
Organization
Uzhhorod National University State Higher Educational Institution
popup.description1
The aim of the work is the development and implementation of innovative biotechnological approaches related to the human microbiome to solve the diagnostic and therapeutic component of the most common challenge of war - post-traumatic stress disorders of military personnel and the civilian population of Ukraine.
popup.description2
Within the framework of this stage, a selection and analysis of biomarkers relevant for the early diagnosis of PTSD was conducted, with particular emphasis on gut microbial compositions. Key alterations in the intestinal microbiota of individuals with post-traumatic stress symptoms were identified, and novel primers were selected for use in rapid diagnostic testing. An innovative open-access database of food products and bioactive compounds was developed [https://microbiotadb-a6d80522104e.herokuapp.com/]. Personalized microbiome correction strategies were modeled in silico, and the biological activity of pro-, pre-, pharma-, psycho-, immuno-, and postbiotics was assessed in vitro. Prototypes of a biotherapeutic formulation and functional food products for PTSD prevention were developed.
Product Description
popup.authors
Burmei Svitlana A.
Drobnych Volodymyr H.
Korol Nataliia I.
Lypei Ivan M.
Mynia Oleksandr Yo.
Pallah Oleksandra V.
Fedorka Pavlo P.
Yusko Lesia S.
popup.nrat_date
2025-06-19
