Registration Number
0225U003768,
(0122U001862)
, R & D reports
Title
New biomimetic catalysts for the cleavage of nucleic acids, organophosphorus ecotoxicants and analogues of toxic warfare agents
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Узагальнення результатів досліджень та надання рекомендацій для отримання нових металовмісних сполук та функціональних матеріалів з покращеними властивостями на їх основі.
Head
Vadym O. Pavlenko, Доктор хімічних наук
Registration Date
15-08-2025
Organization
Taras Shevchenko National University of Kyiv
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Development of scientifically sound approaches to the creation of functional materials based on complexes of transition metals with polynucleative ligands - derivatives of 1H-pyrazole, which would be highly effective catalysts for the cleavage of compounds with phosphoester bonds; development of methods for the synthesis of mono- and binuclear coordination compounds of transition metals based on chelated and binuclear ligands of the pyrazolate type, study of the relationship between their molecular structure, nature of metal ions, physicochemical (spectral, magnetic, electrochemical) parameters and catalytic efficiency cleavage of phosphoesters and development on this basis of a strategy for creating a new generation of highly efficient catalysts for hydrolytic cleavage of compounds with phosphoester bonds.
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The development of effective methods for the cleavage of phosphoester bonds is one of the important problems of modern chemistry and biotechnology, the solution of which is of great importance for the development of genetic engineering, strengthening national security and solving environmental problems. The project is dedicated to the development of new synthetic systems for the efficient cleavage of phosphoesters. The goal of the project is to develop scientifically based approaches to the creation of functional materials based on metal complexes that would be highly effective catalysts for the cleavage of compounds with phosphoester bonds; development of methods for the synthesis of coordination metal compounds, with a main emphasis on mono- and polynuclear complexes based on chelate and binuclear pyrazolate ligands, study of the relationship between the features of their molecular structure, the nature of metal ions, physicochemical (spectral, magnetic, electrochemical) parameters and catalytic efficiency in phosphoester cleavage reactions and development on this basis of a strategy for creating a new generation of highly efficient catalysts for the hydrolytic cleavage of compounds with phosphoester bonds. The project involves searching for rational synthetic routes to obtain target coordination compounds that catalyze the cleavage of a wide range of phosphoesters, their characterization using a combination of various analytical and physicochemical methods. Ways of using new materials as effective catalysts for the cleavage and neutralization of organophosphorus pesticides and toxic substances will be identified.
Product Description
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Bibik Yurii S.
Vynohradov Oleksandr S.
Holenia Іryna О.
Huralskyi Illia O.
Malinkin Serhii O.
Partsevska Sofiia V.
Slyva Tetiana Yu.
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2025-08-15
