Registration Number
0226U001961,
(0123U104821)
, R & D reports
Title
To study the effect of AntagomiR-137 on brain mechanisms of correction of disorders caused by alcohol consumption (experimental study)
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Вивчити вплив антагоміру-137 на мозкові механізми корекції розладів внаслідок вживання алкоголю (експериментальне дослідження)
Head
Berchenko Olha H., д.б.н.
Registration Date
04-02-2026
Organization
State institution "Institute of Neurology, Psychiatry and Narcology, National Academy of Medical Sciences of Ukraine"
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To study the effect of intranasal administration of the liposomal form of AntagomiR-137 on neuro-transmitter, neurotrophic and neurosteroid mechanisms of correction of emotional, motivational and cog-nitive disorders caused by alcohol consumption
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Report on scientific and research work – 110 p., 16 tables, 18 figures, 4 formulas, 1 supplement, 139 sources.
ALCOHOL MOTIVATION, EMOTIONS, MEMORY, NEUROSTEROIDS, GABA, BDNF, ANTAGOMIR-137.
The object of the study – 102 laboratory rats.
Aim: to study the effect of intranasal administration of Antagomir-137 in the form of liposomes on GABAergic, neurotrophic and neurosteroid mechanisms of correction of emotional, motivational and cognitive disorders due to alcohol consumption.
Methods: neuroethological, neurophysiological, biochemical (enzyme immunoassay), mathematical, statistical.
Voluntary ad libitum alcohol consumption causes a high level of ethanol preference in 71% of rats in the 2-bottle test, affects the implementation of anxiety-phobic behavior, increases the baseline level of anxiety and leads to impaired short-term and long-term working memory; causes an imbalance in the brain system of GABAergic and hormonal-neurotrophic regulation with a decrease in the level of BDNF in the brain structures and blood serum of rats. Intranasal administration of Antagomir-137 in the form of lipo-somes maintained the motivational craving for alcohol, but contributed to a decrease in the dose of alco-hol consumed, restrained the level of anxiety and influenced the improvement of cortical mechanisms of short-term and partially long-term working memory. This is due to the restoration of modulatory neuro-steroid balance in the frontal neocortex, amygdala, and blood serum under the influence of Antagomir-137 and its differential effect on the content of BDNF and GABA in brain structures: normalization of BDNF and GABA levels in the neocortex, slowing down the decline in BDNF along with the restoration of GABA levels in the amygdala and the absence of their changes in the hippocampus.
Product Description
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Shliakhova Anna V.
Sokolik Viktoriia V.
Anna M. Titkova
Olena O. Prikhodko
Valentyna V. Heiko
Olha V. Kyrychenko
Nataliia O. Levicheva
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2026-02-04
