Registration Number
0226U002136,
(0123U100711)
, R & D reports
Title
To develop a method of antitumor therapy of primary malignant bone tumors, based on magnetochemical technology using nanocomplexes
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Оцінити можливості клінічного застосування методики протипухлинної терапії первинних злоякісних пухлин кісток, засновану на магнітохімічній технології з використанням нанокомплексів.
Head
Orel Valerii E., Доктор біологічних наук
Registration Date
09-02-2026
Organization
National Cancer Institute
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To improve the effectiveness of complex treatment of patients with bone sarcoma of high degree of malignancy.
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A method for the complex therapy of malignant mesenchymal tumours based on the combined effect of liposomal doxorubicin and electromagnetic irradiation has been developed. Experiments with Saos-2 osteosarcoma cells showed that the combined effect of liposomal doxorubicin and electromagnetic irradiation on Saos-2 cells increased the induction of early apoptosis by 12% (p < 0.05) compared to the independent action of the drug, the number of active oxygen species by 23% (p < 0.05) and the level of Bax protein expression by 107% (p < 0.05) compared to the control.
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Product Description
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Olha Y. Dasiukevych
Anatolii H. Diedkov
Oleksandr Y. Rykhalskyi
Vasyl V. Ostafiichuk
Valery Orel
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2026-02-09
