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Information × Registration Number 0226U002136, (0123U100711) , R & D reports Title To develop a method of antitumor therapy of primary malignant bone tumors, based on magnetochemical technology using nanocomplexes popup.stage_title Оцінити можливості клінічного застосування методики протипухлинної терапії первинних злоякісних пухлин кісток, засновану на магнітохімічній технології з використанням нанокомплексів. Head Orel Valerii E., Доктор біологічних наук Registration Date 09-02-2026 Organization National Cancer Institute popup.description1 To improve the effectiveness of complex treatment of patients with bone sarcoma of high degree of malignancy. popup.description2 A method for the complex therapy of malignant mesenchymal tumours based on the combined effect of liposomal doxorubicin and electromagnetic irradiation has been developed. Experiments with Saos-2 osteosarcoma cells showed that the combined effect of liposomal doxorubicin and electromagnetic irradiation on Saos-2 cells increased the induction of early apoptosis by 12% (p < 0.05) compared to the independent action of the drug, the number of active oxygen species by 23% (p < 0.05) and the level of Bax protein expression by 107% (p < 0.05) compared to the control. Translated with DeepL.com (free version) Product Description popup.authors Olha Y. Dasiukevych Anatolii H. Diedkov Oleksandr Y. Rykhalskyi Vasyl V. Ostafiichuk Valery Orel popup.nrat_date 2026-02-09 Close