Search academic texts

Information × Registration Number 0215U000742, 0112U005999 , R & D reports Title The value of the natural metabolite of glucosamine hydrochloride in the processes of aging (age-related effect on reproductive function) popup.stage_title Head Yakovleva Larisa Vasilivna, Доктор фармацевтичних наук Registration Date 07-04-2015 Organization Nation University of Pharmacy popup.description2 Object of study - substance glucosamine hydrochloride. Purpose - to study changes in reproductive function in aging male rats, reproductive aging relationship with the level of endogenous metabolite N-acetylglucosamine, efficacy of exogenous glucosamine hydrochloride and study the possibility of using it as a proofreader reproductive function. Methods: pharmacological, biochemical methods of mathematical statistics. Results. The increase in the aging of total N-AtsHA, which is due to increase idle in metabolism aminotsukru free fraction, indicating that age-dependent changes in endogenous serum glucosamine male rats. Introduction glucosamine hydrochloride rats of different ages slows aging of the reproductive system of rats: a means of recovering under a mass of genitals and sperm parameters of the functional state, state of spermatogenesis, indicating that the recovery of rat spermatogenic function of old age and a Geroprotective effect of glucosamine hydrochloride. Analysis of the data suggests that the positive effects of glucosamine hydrochloride is realized through its membranoprotektornym and antioxidant properties. Introduction of exogenous glucosamine restores the pool of active fractions of glucosamine and thus helps to restore damaged structures of cell membranes, the normalization of intercellular interactions, trophic improvement.5481 Product Description popup.authors Єрьомін О.П. Ковальова Є.О. Кошова О.Ю. Лар'яновська Ю.Б. Лебединець І.О. Палагіна Н.В. Свічкар Ю.В. Шевченко Л.О. Юдкевич Т.К. Яковлєва Л.В. popup.nrat_date 2020-04-02 Close