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Registration Number

0224U031510, 0122U001535 , R & D reports

Title

Transport of ions and oxalates as a key factor in chronic kidney disease and associated pathologies

Head

Zholos Oleksandr V., Доктор біологічних наук

Registration Date

03-05-2024

Organization

Taras Shevchenko National University of Kyiv

Description

A study of the development of renal failure with rhabdomyolytic damage to the muscle soleus of rats using the glycerin model and muscle injury with intraperitoneal administration of powerful antioxidants – solutions of C60 fullerenes was conducted. New antioxidant methods of influencing the development of kidney failure have shown the effectiveness of injections of an aqueous solution of C60 fullerene, which is able to neutralize the toxic effect of myoglobin. A 20-45 % decrease in the levels of biochemical markers of GPN was shown when using injections of an aqueous solution of C60 fullerenes. The obtained data show a significant concentration-dependent decrease in the level of renal failure when using injections of C60 fullerenes, which can affect the activity of endogenous antioxidants, preventingtheoccurrenceofrenaldysfunction. At 10 weeksaftertheinductionof GPN, the experimental group had statistically significantly lower oxalate excretion and higher concentrations of serum creatinine, total cholesterol, and total cholesterol compared to the control group. The level of serum creatinine was directly associated with total cholesterol and blood sugar, and was also inversely associated with the daily excretion of oxalate in the experimental group. It was established that under conditions of hypotonic stress, which is accompanied by tissue swelling, mechanosensitive TRPV4 ion channels are activated, leading to increased contractility of the myometrium of pregnant rats. Suppression of the characteristic biphasic contractile response of pulmonary arteries of rats with experimental nephropathy in response to the selective agonist of TRPV4 channels, GSK1016790A, against the background of preliminary vasoconstriction with phenylephrine is shown. A new concept of bidirectional molecular and functional signaloplex TRPV4-PZKK-L-RyR-BKCa in vascular smooth muscles is proposed.

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Bohatyrov Roman Yu.
Dovbynchuk Taisa V.
Melnyk Mariia I.
Moroz Olesia F.
Nozdrenko Dmytro M.
Soroka Vasyl M.
Stepanova Nataliia M.
Stetska Viktoriia О.